I have had success hunting Hydras with this:
10+2 Sword
10+1+1 Strength
11 WS
(think that's how the runes are setup. in any case it's 12/12/11)
Sever
Gash
Apply Poison
Warrior's Endurance
Dryder's Defense
Dolyak
Unguent
<anything>
Actually had Charm Animal in that last slot since I was there leveling a pet, but Sprint would be useful (although it would prevent you going into WE right away b/c of energy). Basically Apply, run, Dolyak, WE, <hack>, Unguent as needed.
Otherwise, just keep Dolyak going, save Dryder's for emergencies since it makes you nearly invulneralbe for 9 seconds, and watch Poison + Sever + Gash go to work.
Trying to spread poison around isn't very helpful. Taking that first target down is more important when dealing with 3. More than 3 is a problem. A "-x dmg while in stance" shield is helpful.
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